Speculation of Nano-gap Sensor for DNA sequencing technology: A Review on Synthetic Nanopores

Abstract

Nano-gap sensor is the next generation of single molecule analysis that consumes less resources, costs, times and spaces. The ultimate goal of this technology is rendering the ability to determine any living genetic code in several seconds using a portable device. In principle, DNA decryption was determined by tracking electrical signal change when DNA is passed through either natural or synthetic nanometer size gap. This review focuses on the synthetic nanopore, which is more robust, reliable and manageable with ease. Biological nanopore has been researched in parallel; however, the device reproducibility is a controversial issue. The history and development toward the future of this prospect technology will be elaborated attentively. The main limitation of nanopore sensor device is the controlling of DNA translocation dynamic through tiny pore. Many attempts had been tried and the synopsis will be contemplated in the review. Nonetheless, the present results of DNA sequencing have not been satisfied, the development of nanogap sensor is promising for genomic sequencing and molecular biology.